I want to add to this. (will post details later when I get some more time, plus there are other threads out there on this)
The game itself I believe will work. After the install, if you are to start the ndlauncher.exe, it brings up the startup menu. (configure video options, start the game, etc...)
After you click start, and Game Guard attempts to start up is when the game crashes.
Any game that has Game Guard included DOES NOT work under crossover or wine. This has been known for some time now, and this has some great in depth details over at wine-hq.
Most of the "free" online MMORPG games (lots of double speak there :P) has Game Guard, and these games do not work because of it. (shaiya, last chaos, project torque, 9dragons: just to name a few)