Deus Ex (Game of the Year Edition) works well with CX 5.0 Professional.
Installer worked well. After installation, add the following to user.reg:
[Software\\Wine\\AppDefaults\\DeusEx.exe\\X11 Driver] 1132804623
"Desktop"="N"
"Managed"="N"
Select DirectX the first time the game is run.
Game runs in full screen at the selected resolution. The resolution can be changed in the settings and immediately takes affect. Sound works as well. The game was response on my 2.6GHz PIV.
Distribution is Kubuntu Breezy.