As per a whole number of Wine/CX games in Linux (bug 6971), the mouse still leaves the screen in windowed mode, and can't really be played at all in full-screen mode (unless you're ok with not being able to rotate the view 360 degrees to see things behind or beside you). In windowed mode, while running Metacity, I can open up the Compiz config settings manager, I can disable or enable "Rotate Cube" (doesn't seem to matter if it's on or off, only that it changes) while in windowed mode to get the screen to grab the cursor. Since the setting only seems to need to change - and not to be either disabled or enabled - I can only do this while actually running the game. I'd do it while in full-screen mode to get the same effect, but every time I alt-tab out of the game while in full-screen mode, the program mysteriously disappears. It still runs, but I can't get back into it.
If somebody has figured out a better way, I'd appreciate knowing, but the last time I checked, the bug in WineHQ was still very much active.
Too bad too... when I saw that gold medal and the installer file, I got my hopes up... but this game is still a silver at best.