Game appears to be working without problems under Crossover Games 8.0 on my MacBook Pro (Core2 Duo 2.33, Radeon Mobility x1600, 10.6.4). Was able to install, patch, and play - I didn't do a whole lot of testing, but ran around my Relto, linked to a few Ages and a couple of City locations.
Requires a Windows XP bottle (for PhysX install), and I did install DirectX (Legacy). Other than that, no tweaks. Haven't tested 9.0 yet - I haven't upgraded because of issues with Dungeons and Dragons Online - but if I get a moment I will check it out.