Hello,
I've installed Crossover and STO via CrossTie on a MacBook Pro. Specifications are:
Model Name: MacBook Pro
Model Identifier: MacBookPro5,1
Processor Name: Intel Core 2 Duo
Processor Speed: 2.4 GHz
Number of Processors: 1
Total Number of Cores: 2
L2 Cache: 3 MB
Memory: 4 GB
Bus Speed: 1.07 GHz
Boot ROM Version: MBP51.007E.B06
SMC Version (system): 1.33f8
The installation itself seemed to go well. When I launch STO, however, I receive this error message in a new window titled "Star Trek Online".
Bad Request
Your browser sent a request that this server could not understand.
Request header field is missing '.' separator.
EEEEEE x86
With a bit of further searching, I came across this thread on the STO forums. It is devoted to an unofficial Mac wrapper that some people are using to play the game. I hope this is of some help.
http://sto-forum.perfectworld.com/showthread.php?t=76799&page=116