Well first of, if the game is mentioned as already running you need to kill the old process before any further testing can be done.
It may not be a complete answer, but I would recommend you kill the process TESV.exe, SkyrimLauncher.exe before proceeding. It might be easier though if you simply used the crossover tool GUI options to kill the entire bottle, restarting everything. As I said though, this may not be an answer to your specific issue, but it needs to be done before you retry anything.
It also happens on my skyrim, but my OS is linux. The weird thing is that the game used to run smooth and without any issue until one day. I think it may be related with a crossover update? Or may be a steam update? The issue started the fisrt days of March (2015).
We're rebels. We're misfits. But mostly, we're software liberators. And we're very, very good at what we do. We have to be. Lots of developers work with open source, but only a tiny fraction of those are good enough to get software that was designed for one platform to work on another one. We invented CrossOver software - a unique approach to cross-platform compatibility that does not require dual-boot or another OS license. We launched PortJump to help app and game developers broaden their market beyond Windows® users. And we launched ExecMode to help organizations solve really ugly technical challenges.