Skyrim (include Dawnguard, Dragonborn & Hearthfire) works perfectly on Crossover 14.1.3.
Additional installation: DirectX 9, DirectX Modern, .NET 2.0, SP1, SP2, 3.0, 3.5, 3.5 SP1, .NET 4.0, Virtual C++ 2010
Additional mods:
Vanilla Reduced Textures 512 Legendary v25
Pine Needles FX
Rainfall FX
Snowfall FX
The Rift - Aspen Leaves FX - Super Performance
Low Res Fire Effects and Spells - v1
Low Res Plants and Flowers - v1
Low Res Smoke - v3
Fog Mesh Remover
Texture setting is High, other settings are Medium.
iMac mid 2011 Quad-core 2.5GHz, AMD HD 6750m 512MB, RAM 12GB, OS X 10.10.3