The Elder Scrolls V: Skyrim
Not enough memory to run application
Close Steam and then go to Programs>Run Command, select the Skyrim bottle, enter "regedit" in the Command: field and press Run.
Within regedit, browse to HKEY_CURRENT_USER/Software/Wine/Direct3D
in here, add a new string value called "VideoMemorySize" and set it to "512".
If this has no effect, you might try going to back and setting "VideoMemorySize" to "1024".