ChemDraw 17 and 17.1 were functionally unusable prior to Crossover 18.0.0, but I can report the crossover upgrade got things working. I'd installed on a Win7 bottle with the prior (ChemDraw 15/16) protocol, and tried upgrading things like .NET, to no avail--it crashed on opening any of the subpalettes (arrows, orbitals, etc.) CO 18 fixed that and it seems to be a usable daily driver. I even got a Greek font back.
It's not 100%; the Templates icon crashes it (though the .cdp files can be opened from the menu and copy/pasted); the Page Setup also crashes. The integrated SciFinder search seems inoperable.
Still, quite functional for the main use of generating figures for pasting into documents & presentations.