[edit - this answer applies to GNOME 3, and there is probably an easier way of doing it that I haven't figured out, yet]
Looks like the answer is "yes", though I haven't gotten it down perfectly, yet.
For basic functionality, i.e. Outlook itself opens when clicking on a "mailto" link, modify this file
and where you see
copy in the the Outlook desktop file, which you'll find in that same directory. Its full and proper name will be something like
Remember to put a ";" at the end of the .desktop file entry. As mentioned, this will just open up Outlook, itself. No further action will be taken, and if Outlook is already open, you'll get another Outlook window. Annoying.
So, I created a new .desktop file in ~/.local/share/applications called
by opening up the standard .desktop file, and changing "Exec=" to
Exec=/opt/cxoffice/bin/wine --cx-app outlook.exe -c IPM.Note /m "%1"
(see for reference: http://support.microsoft.com/kb/312346)
which will only work if your MS Office 2007 bottle is set as default inside manage bottles.
So, with this new "mailto.desktop" file in the "x-scheme-handler/mailto=" fields within the mimeapps.list file, clicking on a mailto link in firefox will open up a new message window in outlook. But...the "to" field is blank in the message.
If you're able to perfect the process, let me know! That's about as much time as I have to mess with this for now.