There's some work going on in Wine, partially on our account, to get this going. Printer drivers usually do not need low level hardware access. Most of them either write to a network printer(no issue), to a parallel port(no issue, can be emulated and wrapped to /dev/lp0 or USB(the same).
The trouble with printer drivers is that most of them need a DIB engine, as well as some interfaces that do not exist yet. SuSE has a printer driver wrapper that gets drivers working that do not need a DIB engine, and a DIB engine is planned after the Wine 1.0 release.
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