If ClamAV or any other virus scan is enabled on Linux, CrossOver will scan Windows programs before they are run. Windows programs are susceptible to virus infections so enabling the scan is an excellent idea.
If something within a CrossOver bottle fails the virus scan, CrossOver will refuse to run the executable file. It will display the name of the file that it attempted to run and the name of the virus that caused the failure:
CrossOver Security Warning
A virus was found in the '....drive_c/Program Files/Microsoft Office/Office14/OUTLOOK.EXE' file.
It will thus not be run in order to protect your computer.
../drive_c/Program Files/Microsoft Office/Office14/OUTLOOK.EXE: Win.Trojan.Bancos-2115 FOUND
Clamav and other Linux virus scan tools do not disinfect files by default. We recommend referring to your distributions page regarding the tool.
We're rebels. We're misfits. But mostly, we're software liberators. And we're very, very good at what we do. We have to be. Lots of developers work with open source, but only a tiny fraction of those are good enough to get software that was designed for one platform to work on another one. We invented CrossOver software - a unique approach to cross-platform compatibility that does not require dual-boot or another OS license. We launched PortJump to help app and game developers broaden their market beyond Windows® users. And we launched ExecMode to help organizations solve really ugly technical challenges.