If ClamAV or any other virus scan is enabled on Linux, CrossOver will scan Windows programs before they are run. Windows programs are susceptible to virus infections so enabling the scan is an excellent idea.
If something within a CrossOver bottle fails the virus scan, CrossOver will refuse to run the executable file. It will display the name of the file that it attempted to run and the name of the virus that caused the failure:
CrossOver Security Warning
A virus was found in the '....drive_c/Program Files/Microsoft Office/Office14/OUTLOOK.EXE' file.
It will thus not be run in order to protect your computer.
../drive_c/Program Files/Microsoft Office/Office14/OUTLOOK.EXE: Win.Trojan.Bancos-2115 FOUND
Clamav and other Linux virus scan tools do not disinfect files by default. We recommend referring to your distributions page regarding the tool.