macOS Catalina has increased some security measures, and users are now required to manually grant access to more applications than in previous versions of macOS. If you are receiving permission denied errors, you may need manually give your program access.
Open your System Preferences.
Click on Security & Privacy.
Click on the Privacy tab.
Scroll down the column on the left-hand side to Files and Folders.
If CrossOver (or an application installed via CrossOver) doesn't have checkmarks next to it, click the lock button in the lower left and check all of the boxes for applications that you know and trust.
We're rebels. We're misfits. But mostly, we're software liberators. And we're very, very good at what we do. We have to be. Lots of developers work with open source, but only a tiny fraction of those are good enough to get software that was designed for one platform to work on another one. We invented CrossOver software - a unique approach to cross-platform compatibility that does not require dual-boot or another OS license. We launched PortJump to help app and game developers broaden their market beyond Windows® users. And we launched ExecMode to help organizations solve really ugly technical challenges.